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Targeting intermediary metabolism Farnesoid X receptor (FXR) agonists The nuclear FXR agonists may treat MASLD through various mechanisms, including alleviating insulin resistance and exerting direct anti-inflammatory and antifibrotic effects on MASH in both mouse models and human tissues

J Biol Chem 1980;255:93449352

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The effect of the magnitude of weight loss on non-alcoholic fatty liver disease: A systematic review and meta-analysis

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