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In rabbit models, intra-articular injection of scAAV2 encoding interleukin-1 receptor antagonist (IL-1Ra) yielded sustained therapeutic protein expression in both inflamed and normal joints for at least two weeks, with minimal immune activation or joint pathology (178)

This has not been demonstrated in clinical practice with oral glutathione at standard supplemental doses, but preclinical evidence warrants caution in cancer patients undergoing active treatment [2][5]

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Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress