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Long-acting glucagon-like peptide-1 receptor agonists have direct access to and effects on pro-opiomelanocortin/cocaine- and amphetamine-stimulated transcript neurons in the mouse hypothalamus

a dose-dependent heart rate increase was also observed, consistent with incretin-class effects

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Perhaps its most famous role, GLP-1 crosses the blood-brain barrier to act directly on appetite centres in the brain, enhancing feelings of fullness and reducing hunger signals

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