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What are GLP-1 and Peptide Y
eGFR, estimated glomerular filtration rate
Potential implications of the new pharmacotherapies on obesity management The mean WL in clinical trials with the most efficacious new obesity pharmacotherapies ranges between 15% and 25% at 1 year (and it may be even higher for some agents that have not reached weight plateau at study completion)
Interestingly, colonic L-cells possess twice as much total GLP-1 compared to L-cells from the upper GI tract (53)
Its highly unlikely that a small patch could deliver anywhere near these therapeutic amounts through the skin
This helps prevent receptor desensitization, keeps results consistent, and minimizes unwanted side effects
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