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The blood concentrations of acylcarnitines with saturated long-chain fatty acids were 0.09 0.05 mol/L, 1.02 0.32 mol/L, 0.39 0.14 mol/L, 0.01 .007 mol/L, 0.001 0.002 mol/L and 0.001 0.003 mol/L for myristoylcarnitine (C14), palmitoylcarnitine (C16), stearoylcarnitine (C18), hydroxymyristoylcarnitine (C14OH), hydroxypalmitoylcarnitine (C16OH) and 3-hydroxystearoylcarnitine (C18-OH), respectively, in the patients group

Sci Rep (2015) 5:12898.10.1038/srep12898 59 UdagawaNTakahashiNAkatsuTTanakaHSasakiTNishiharaTet alOrigin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells

With four compounds and twelve possible interaction pairs, troubleshooting is substantially more complex than with a three-compound protocol

Mechanisms underlying these observations have been investigated

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