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It is a feedback loop

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Research has found that tectorigenin can reestablish this equilibrium in asthmatic mice by upregulating the expression of Th1-associated factors while suppressing Th2 cytokines such as IL-4, IL-5, and IL-13, consequently reducing serum IgE levels

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S4b), perfectly explaining the critical physiological fact that gastrin-17 selectivity activates CCK2R but not CCK1R in the gut where both CCKRs spontaneously exist and modulate distinctive physiological and pathological processes