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Description

the nasal mucosa does not transport molecules above roughly 1000 Da efficiently

In contrast, SL apomorphine may cause oropharyngeal irritation, including tissue swelling (~ 15%), pain (~ 13%), ulceration (~ 7%) or erythema (~ 7%), that is a more frequent cause of discontinuation (~ 17% of patients in a 12-week trial) and can prevent continued use of the product [10, 13]