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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons
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Additionally, the invention relates to a pharmaceutical or diagnostic composition comprising the BPC peptide salts of the present invention, optionally in conjunction with one or more pharmaceutically acceptable carriers, as well as processes for preparing these compositions
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