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Early-phase clinical trial data, including results from a Phase 2 trial published in the New England Journal of Medicine in 2023, demonstrated mean weight loss of up to approximately 24% of baseline body weight at 48 weeks in adults with obesity who did not have type 2 diabetes

2020), with clinical benefits detailed in cardiovascular outcome studies (see Sect

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c) study utilized a cross sectional design to study changes in % FMD following a GLP-1-based therapy

Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice

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