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Self-administration of PCT medicines was reported by 73% of men discontinuing AAS in Scotland between 2015 and 2022 (Grant et al., 2023a) and by 80% of 100 male athletes in the Netherlands between 2015 and 2018 (Smit et al., 2021)

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Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of 1 Adrenoceptor and Dopamine D1 Receptor Pathways in the Diet-Induced Obese Rat