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The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined

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So far, the mechanisms underlying the protective effects of GLP-1RA in respiratory disease are not fully understood

It is still a good and safe option for type 2 diabetes management , but as a weight-loss drug, it has largely been replaced by stronger next-generation treatments

Recent Phase 3 data showed average weight reduction exceeding 28% in some participant groups after extended treatment periods

NRF2 not only orchestrates the antioxidant gene response to battle ROS but also fortifies mechanisms like mitophagy, which is pivotal for mitochondrial integrity