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Reductive stress-induced mitochondrial dysfunction and cardiomyopathy

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In small doses, they can cause fever, tiredness and aches, but in large amounts, they can trigger life-threatening conditions like septic shock

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Increased levels of H 2 O 2 can form extremely reactive hydroxyl radicals through Fenton reactions with free iron present in the cytoplasm, which has downstream negative effects on intracellular calcium levels, protein synthesis, glycosylation, and redox status ( Figure 2E )