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Gout can develop in a person either because they are producing too much uric acid or because they are unable to put enough of it into the urine (or both)

Treatment doses for deficiency are substantially higher, typically involving intramuscular injections of 1,000 g or oral supplementation of 502,000 g daily, depending on the underlying cause and severity

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Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA, RNA, and proteins ( Figure 1 ) (3)