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It has been proposed that damage caused by ROS and RNS including HNE causes impaired glucose metabolism and electrochemical gradients across membranes which in turn affects calcium homeostasis (Butterfield and Halliwell 2019)

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Hayes, C

62 Moreover, CPTIC is an essential downstream mediator of the AMPK pathway as well as a target gene of p53 in a p53/AMPK-dependent manner

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