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The prescription of certain VGSC-inhibiting drugs already in clinical use, such as antiepileptic drugs and antiarrhythmic agents, has been associated with reduced cancer incidence and improved survival in retrospective studies (329, 330)

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When there is sufficient reduced glutathione in the cells, they sacrifice themselves to free radicals to protect cellular mitochondria

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Card JP, et al

For example, an hour is attained when 31 minutes have elapsed (more than midway between zero and 60 minutes)..." HOWEVER, this is not across the board

To minimize these events, Sean Wharton, MD, director of the Wharton Medical Clinic in Toronto, and colleagues suggest the three Es: E ducation and explanation E scalation to an appropriate dose E ffective management of GI side effects. Patients should be counseled on means to decrease adverse event risk such as reducing meal size