Ethics statement The animal study was reviewed and approved by the ethics committee of Shanghai Jiao Tong University School of Medicine, Shanghai, China
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11 Packer MZile MRKramer CM Tirzepatide 2025;392:427-37
Functional sepiapterin reductase is a homodimeric enzyme which first converts 6-pyruvoyltetrahydropterin to 1-hydroxy-2-oxopropyltetrahydropterin, which is then reduced to 1-oxo-2-hydroxypropyltetrahydropterin, and then finally to 5,6,7,8-tetrahydrobiopterin, BH 4
So, the bottom line is that both medications are effective in helping patients lose weight when combined with diet and exercise
Medication indications, formulations, availability, safety guidance, pricing, and coverage can change