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4.3 Alleviation of oxidative stress via the Nrf2 system The pivotal role of the Nrf2/NF-B signaling nexus in aristolochic acid I (AA-I)-induced nephrotoxicity was rigorously investigated by 4.4 Restoration of autophagy and cellular homeostasis The research by Acteoside as a pharmacological agent capable of ameliorating fibrosis in diabetic nephropathy models

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Their ability to simultaneously address multiple pathophysiological mechanismsincluding insulin resistance, hepatic lipotoxicity, and inflammationdistinguishes them from previous therapeutic approaches

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