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A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)

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doi: 10.1038/s41574-019-0218-2 85 PeetersRPWoutersPJKapteinEVan ToorHVisserTJVan Den BergheG

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Cell culture to assess SnCE1 proteolytic processing Human embryonic kidney cell line (HEK-293) obtained from ATCC (CRL-1573) was used