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However, in a previous study carried out in Calu-3 cells, it was shown that exposure to cigarette smoke causes a decrease in the synthesis of CFTR mRNA, which was reflected in the expression of the protein [121]

doi: 10.1152/ajprenal.00164.2016 11 LansHHoeijmakersJH

The rectal mucosa displays several inespecific ulcerated lesions

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However, significant weight loss may take a longer duration, potentially a few months, as the body adjusts to the medication and the changes in appetite and metabolism it induces