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The follicle is embedded within an extracellular matrix (ECM) a complex scaffolding of proteins including collagen, laminin, and fibronectin that provides structural support, facilitates cellular communication, and delivers biochemical signals essential to follicular function
Piran R, Lee SH, Kuss P, Hao E, Newlin R, Milln JL, et al (2016) PAR2 regulates regeneration, transdifferentiation, and death
Visceral adipose tissue releases inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha)
The half-life of DSIP depends on its environment: In vitro, it exhibits low molecular stability due to the action of specific aminopeptidase enzymes, with a half-life of only 15 minutes
Bailey et al., 1997
It is widely recognized that with aging, cell function, and metabolism are affected and the self-repair capacity of cells decreases [43]
