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The program rested in part on the expectation that improving biomarkers and engaging the target would track with clinical benefit, a logic laid out in the published rationale and design of the trials

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D'Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, et al

Among all adults, 7% say they have taken or are taking these drugs to treat a chronic condition such as diabetes or heart disease either alone (5%) or in combination with intent of losing weight (3%) while 5% of adults report ever taking these drugs to lose weight but not to treat a chronic condition

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