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3.1.1 Indoxyl sulfate (IS) Indoxyl sulfate (IS) is classified as a protein-bound uremic toxin, with its biosynthesis originating from tryptophan metabolism: gut microbiota first convert tryptophan into indole, which is then transported to the liver for oxidation and sulfation to form IS (Meyer and Hostetter, 2012)

In addition, some of the products contained compounds even more effective than the antidote (NAC) when treated after APAP administration

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Dihydroartemisinin: a potential natural anticancer drug

OA-NPs@OA represents a paradigm-shifting approach that exhibits superior therapeutic efficacy by virtue of targeted delivery, multimodal mechanisms of action, and its inherently high biosafety