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After 72 weeks, participants on Zepbound lost an average of 20.2% of their body weight (averaging 50 pounds), compared to 13.7% (around 33 pounds) for those on the 2.4 mg dose of Wegovy (later studies of the 7.2 mg dose of Wegovy have showed 18.7% weight loss)
Given the strong link between sleep function and depressive states, this peptide, which appears to influence the sleep cycle, could also be of research interest in the context of depression onset
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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: March 16, 2026 BPC-157 typically begins working within the first one to two weeks, with most patients noticing subtle improvements such as reduced soreness, better digestion, and decreased inflammation during this early phase