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Some portion of intranasally administered peptides may reach the central nervous system through the olfactory pathway, bypassing the blood-brain barrier
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In vivo assessment of high-fat-fed Trpm5 / mice demonstrated the absence of triagonist-induced therapeutic effects on glycaemic management
Co-infusion of GLP-1 and GCG has been shown to reduce glucagon-induced hyperglycemia, lower blood glucose levels, suppress food intake, and enhance energy expenditure in both diabetic obese mice and healthy human volunteers [78]
The damage caused by SAP to the vascular endothelium is manifested as the release of inflammatory mediators and leukocyte adhesion, increased vascular permeability, changes in blood flow shear stress, microthrombosis, and microcirculatory disorders
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