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This article traces the mechanistic differences between the three compounds, covers what the peer-reviewed trial data actually show, and explains the engineering decisions behind the dual- and triple-agonist designs

Cava, Edda, Nai Chien Yeat, and Bettina Mittendorfer

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However, the long-term treatment with GLP-1RAs may reduce the insulin levels in both T2DM (122) and prediabetic patients (123), owing to the glycemic normalization and increased insulin sensitivity in these patients

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