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If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs

Classes of significantly altered species are shown for lipids downregulated in Ms4a15 OE and Tgn long (group I), those exclusively enriched in Ms4a15 OE (group II), and those enriched in both Ms4a15 OE and Tgn long (group III) (ESI+, Fig

Translation: potentially enhanced appetite suppression and metabolic benefits

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Severe (II) - less than 10% of normal enzyme activity

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