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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing

Wherever the injection was administered, you could experience some discomfort, swelling, or itching

To maintain GSH homeostasis, part of GSSG is transported to the cytosol through vesicular transport [72]