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Furthermore, the absence of blood flow and the resulting shear stress altered the properties of endothelial cells in transwell models (Cucullo et al., The first BBB model to include potential effects of shear stress and 3D structure was based on an artificial capillary formed by a polycarbonate fiber pre-coated with fibronectin, rat collagen, or poly-D-lysine

The trial also identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients a safety signal that doesn't appear in the cagrilintide literature