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Serious adverse effects require clinical vigilance: Pancreatitis : Patients should be counseled to seek immediate medical attention for severe, persistent abdominal pain radiating to the back, with or without vomiting

Each has distinct mechanisms, indications, and costs

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The kidney expresses GGT at the highest levels, while notable expression is also found in bile canaliculi of hepatocytes, ducts within the pancreas, the apical surface of the intestinal epithelium and the luminal surface epithelium of many reproductive organs (25)