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These antibodies can be polyclonal or monoclonal, and react with GPX4 in Human, Mouse, Rat, and many other animal samples

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Any observed effect could be from the contaminant, not the IGF-1 LR3 itself

Hence, this autoantibody presence especially targets the autonomic and central nervous systems (503), which may explain the dysautonomia and immune dysregulation present in ME/CFS (58)