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MDMA administration led to significant elevations in MDA and 8-OHdG, reductions in antioxidant enzymes (GPx, GST, GSH, SOD), upregulation of inflammatory mediators (MPO, NF-B, TNF-), and disruption of ion homeostasis via altered Na/K ATPase and Ca ATPase activities
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04:48 Tue, Jan 6 20266:01 PM EST
Conclusion Currently, there is a large population of NAFLD/NASH patients who require long-term treatment, yet there is only one approved drug specifically for NASH, Rezdiffra (resmetirom), indicating that the clinical need is far from being fully met
Investigators have proposed that GHK-Cu's central function is to deliver copper to fibroblasts in a controlled, non-toxic form buffering against the redox damage that free Cu would otherwise cause [4]