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The results showed that exendin 939 restored nitrite, PGE 2 , and IL-6 secretion in liraglutide pretreated chondrocytes and macrophages in a dose-dependent manner ( p = 0.0022 compared with IL-1 + liraglutide group and p = 0.026 or p = 0.0022 compared with LPS + liraglutide group)

doi: 10.1038/nature03180 72 RubensteinJ

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Compound 17 effectively reduced IL-1 and TNF- production, as well as the expression of iNOS and COX-2, by inhibiting the MAPK signaling pathway

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