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In contrast, persistently stabilized NRF2 in response to KEAP1 or NRF2 mutations causes sustained activation of these genes, leading to the accumulation of xCT/SLC7A11, GCLC, and GCLM that cause a depletion of intracellular glutamate (Sayin et al

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The mitochondrionor mitochondria, in its plural formis a specialized organelle found in most eukaryotic cells cells that contain a nucleus

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