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While strict inclusion criteria ensured methodological quality, they may have reduced the breadth of eligible evidence, limiting the scope of subgroup analyses and the generalizability of certain findings

It is possible that the niacin/laropiprant combination further reduces the poor tolerability to statin treatment observed in certain populations (135)

This medicalization of obesity makes it significantly more difficult for payers to classify the drug as a lifestyle expense, securing long-term reimbursement and patient stickiness

Martin, K

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