Hormonal Mechanisms of Semaglutide Semaglutide, a GLP-1 receptor agonist, mimics the hormone glucagon-like peptide-1 (GLP-1) produced in the gut
In a study (New-Onset Nonarteritic Anterior Ischemic Optic Neuropathy and Initiators of Semaglutide in US Veterans With Type 2 Diabetes) published on February 12, 2026, participants who started taking semaglutide were about 2 times more likely to develop NAION than participants who took sodium-glucose cotransporter-2 inhibitors
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GPX-like proteins have been reported in many species, the importance of Sec has been recognized, and Sec-based glutathione peroxidase has been extensively studied in mammals, but they appear to play different roles in different locations or cells (Handy et al., 2021)