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In imiquimod-induced mouse models, betulin-loaded NLCs produced marked lesion improvement accompanied by reductions in systemic inflammatory cytokines such as TNF-, IL-6, and IL-17, along with a lowered spleen index, indicating that their therapeutic benefit extends beyond local skin improvement to systemic immunomodulation [123, 124]

Palmitoylethanolamide supports gut lining stability, lowers low-grade inflammation, and improves digestive motility in IBS, potentially easing bloating, abdominal pain, and irregular bowel movements

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The 1 mg dose is primarily about establishing tolerance, not producing dramatic results

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