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Butyrate, in particular, with its potent immunomodulatory properties, inhibits histone deacetylases in dendritic cells and macrophages and activates G-protein-coupled receptors (GPCRs), leading to reduced production of IL-12 and IL-6 and the promotion of regulatory T-cell activation
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Moreover, all pathogenic bacteria can form phenotypically non-growing, dormant cells that are tolerant (but not genetically resistant) to antibiotics [39]
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