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Succinate Dehydrogenase (SDH) and Fumarase: These enzymes also modulate the TCA cycle through their activity in the interconversion of metabolic intermediates, impacting the flow of -KG

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But that protection erodes fast.Stopping for 6 months: 4% increased risk Stopping for 1 year: 14% increased risk Stopping for 2 years: 22% increased risk all compared to staying on.Here is the most striking finding: What 3 years of continuous treatment builds, a year and a half off the drug can undo