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Dissecting primary and secondary senescence to enable new senotherapeutic strategies

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Chronic Dosing Studies Twenty-six-week repeat-dose studies in rats and 52-week studies in cynomolgus monkeys identified decreased body weight and reduced food intake as the primary pharmacological effects

Hamidi S, Iyer PC, Dadu R, Gule-Monroe MK, Maniakas A, Zafereo ME , Wang JR, Busaidy NL, Cabanillas ME

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Anders HJ, Kitching AR, Leung N, Romagnani P