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In particular, recent progress in elucidating the structures of GPCRG protein or arrestin complexes [12,13,14,15,16] and the electron microscopybased architecture of GPCRarrestin complexes [13, 14, 17,18,19,20] has revealed an overlapping interface on the receptor for arrestin and the G [6]

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Another drug, ES2, targets FOXO4 conserved region 3 (CR3) but has a significantly lower selectivity than FOXO4-DRI 25