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This review comprehensively examines the neurotoxic mechanisms, clinical manifestations, and treatment strategies associated with six commonly abused substances: methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide and heroin

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Concerns about IGF-1 include potential effects on cancer risk, acromegalic changes with chronic elevation, and metabolic disruption

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Patients with coexisting diabetes or obesity and Crohn's disease require careful coordination between specialists, as GLP-1 agonists' gastrointestinal side effects overlap significantly with IBD symptoms, potentially complicating disease monitoring and management