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Altered NAD + homeostasis has been linked to multiple diseases affecting different organs, including the brain and nervous system, liver, heart and kidney

In one trial, 16 people placed on experimental bed rest for 3 weeks (in order to increase urinary calcium excretion by causing bone breakdown) and treated with 20 mg per day of the bisphosphonate alendronate had lower urine calcium concentrations, and lower calcium oxalate and calcium phosphate saturations, compared with placebo (Ruml 1995)

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Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ

Despite that, 17% (one in six people) use GLP-1s, and the percentage increase between 2023 and 2024 was more than 20%