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Effects of liraglutide on expressions of lipid metabolism-related genes in rats with T2DM and fatty liver

The most commonly discussed side effects are gastrointestinal, such as nausea, vomiting, diarrhea, constipation, and stomach discomfort

Semaglutide (Ozempic, Wegovy) activates one receptor GLP-1

This can cause severe hypoglycemia (low blood sugar levels) in people who do not have diabetes, necessitating immediate medical attention

Regarding glucose-metabolism, two studies found that GLP-1(9-36), GLP-1 (7-36) and Liraglutide significantly inhibited insulin-stimulated glucose uptake [12, 13], with Liraglutide showing a dose dependent inhibition, with a maximum at a concentration of 1000 nM [12, 13]