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7), a shift toward the oxidized state would act to slow insulin degradation

If the damage goes on long enough, parietal cells can be lost entirely.[ref] Antibodies to parietal cells are found in 90% of patients with autoimmune gastritis

Another promising hypothesis associates PCOS with elevated levels of cortisol: the selective 11-HSD1 inhibitor BVT.2733 (discovery and preclinical) has shown benefits for obesity, insulin resistance, irregular estrous cycles, reproductive hormone dysfunction, polycystic ovaries, ovulatory dysfunction and subfertility