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Those who switched gained back about 14% of the weight they had lost, while those who stayed on tirzepatide lost a bit more around another 5.5%

The oncogenic transformation involves distinct mutational profiles with lower frequencies of BRAF mutations (1015%) compared to cutaneous melanoma, but higher prevalence of KIT mutations (1520%), C-KIT overexpression, and additional genetic alterations including NRAS mutations, GNAQ/GNA11 mutations, and chromosomal aberrations involving 6p25, 6q23, and 8p23

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Lastly, while no significant changes were observed in CD3+ or CD8+ cells, RETA significantly increased PD-1 mean fluorescent intensity (MFI) in CD8+ T cells compared to Veh, suggesting elevated activation of cytotoxic T cells (Fig