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Conversely, blockade of Ang II subtype 1 (AT1) receptors with candesartan is able to decrease the CRH, ACTH, and cortisol response to isolation stress in rats (124,125)

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These are inputs, not stimulants

TGF-, which plays a vital role in the development of PF, can stimulate airway smooth muscle hyperresponsiveness, goblet cell hyperplasia, and increased mucin secretion through Smad signaling (Ouyang et al., 2010

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