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Research Protocol Applications Glucose homeostasis and diabetes mechanism studies Weight management and appetite regulation research Cardiovascular protection and MACE prevention studies Neuroprotection and cognitive enhancement research Chronic kidney disease progression studies NAFLD/NASH mechanism investigations Anti-inflammatory pathway research Combination therapy optimization studies Clinical Translation Potential GLP1-R research applications span from basic mechanism studies to translational research for multiple therapeutic areas

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9 Despite its severity, DN has received comparatively less attention in clinical research and therapeutic development than other diabetic complications, such as nephropathy and retinopathy, necessitating further research

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