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Aside from infectious diseases, medicines, and lifestyle choices, environmental risk factors have also been associated ( 3.1.2 Key factors 3.1.2.1 Genetic factors Multiple genes and loci contribute to the susceptibility and pathogenesis of psoriasis, creating a complex genetic landscape

It is studied in preclinical trials that MC4R is predominantly expressed in hypothalamic nuclei and has extensive published documentation of its role in energy homeostasis and appetite regulation pathways

So, I think its going to be very enlightening over the next three to five years

Is combination therapy still necessary