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The reduction in Phascolarctobacterium populations in IBD patients may impair the production of propionate, thus diminishing the anti-inflammatory effects of SCFAs and contributing to the exacerbation of IBD symptoms

This explains why high levels of oxidative stress is implicated not just in neurodegenerative conditions but cardiovascular diseases as well

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The first twin succumbed to rapid deterioration from severe anemia and the second twin required exchange transfusions but, in both cases, there were no Heinz bodies in the blood film or hemoglobin in the urine (52)

Increases in sympathetic outflow remain the largest safety concern for melanocortin agonists after compounds such as LY2112688 and bremelanotide demonstrated increases in both blood pressure and heart rate in clinical trials (150)