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Mechanistic investigations attribute these effects to enhanced mitochondrial biogenesis and function, upregulation of neurotrophic factors, and inhibition of -syn aggregation, collectively contributing to neuronal preservation [288, 289]

Combination therapies using multiple drugs: one targeting early-stage glutamine catabolism and one targeting the resulting downstream pathway could be an effective way to target glutamine-dependent tumours more specifically by limiting the emergence of compensatory pathways

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Diabetes Care 38 , 132139 (2015)

However, not all children with ASD respond, so testing for FRAAs with FRAT is crucial before treatment.